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sparsentan will lower the level or impact of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and lowers efficacy linked to these substrates.Modafinil seems to become Risk-free for extended intervals at reasonable (100–two hundred mg) day-to-day do